Modeling Alzheimer's disease and its effects on the brain's blood vessels and immune system
Alzheimer's disease-replicated brain microphysiological system to model AD physiopathology and its influenceon gliovasculature and immune system
This study is exploring how Alzheimer's disease affects the brain by creating a special model that mimics human brain tissue, helping researchers learn more about the disease and find new ways to help people with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Agri & Tech St Univ NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project ID | NIH-10782978 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of Alzheimer's disease (AD) by creating a specialized model that mimics human brain tissue and its interactions with blood vessels and immune cells. The researchers have developed a brain microphysiological system that incorporates various cell types to replicate the disease's key features, such as amyloid plaques and neurofibrillary tangles. By studying these interactions in a controlled environment, the research aims to better understand how AD progresses and affects brain function. This innovative approach could lead to new insights into potential treatments and interventions for patients with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-onset familial Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with non-familial Alzheimer's disease or other forms of dementia may not benefit directly from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease, potentially slowing its progression or alleviating symptoms.
How similar studies have performed: While there have been various models for studying Alzheimer's disease, this specific approach using a brain microphysiological system is relatively novel and has not been extensively tested in prior research.
Where this research is happening
Greensboro, United States
- North Carolina Agri & Tech St Univ — Greensboro, United States (Active)
Researchers
- Principal investigator: Yun, Yeoheung — North Carolina Agri & Tech St Univ
- Study coordinator: Yun, Yeoheung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.