MitoNEET's role in regulating cellular balance in health and disease
Official title: MitoNEET is a Regulator of the Cellular Thiol State in Health and Disease
Funded at Ball State University · NIH-10875149 · Data updated 2026-11-12
This study is looking at a protein called MitoNEET to see how it helps keep our cells healthy and could lead to better ways to manage conditions like type-2 diabetes, cancer, and Parkinson’s Disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ball State University NIH-funded |
| Lab location | 1 site (Muncie, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $447,337 |
| NIH project number | 1R15GM154239-01 |
| Project ID | NIH-10875149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type-2 diabetes, cancer, or Parkinson’s Disease.
✕Less likely to help
Patients with conditions unrelated to cellular redox balance or those not diagnosed with the target diseases may not benefit from this research.
What this research studies
This research investigates how MitoNEET, a protein found in cells, influences the balance of important molecules that protect cells from damage. By examining its role in conditions like type-2 diabetes, cancer, and Parkinson’s Disease, the study aims to understand how MitoNEET can affect cellular health and potentially lead to new treatments. The approach involves analyzing how MitoNEET interacts with thiol-containing molecules and how its stability can impact cell function and survival. Patients may benefit from insights gained about how to better manage or treat these diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing diseases like diabetes, cancer, and neurodegenerative disorders.
How similar studies have gone: Previous research has shown promising results in targeting cellular redox balance for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
-
Ball State University
Muncie, United States Active
Researchers
- Principal investigator: Konkle, Mary — Ball State University
- Study coordinator: Konkle, Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.