Mitomycin-induced DNA crosslinks: how cancer cells respond and die
Official title: Identification of critical cellular pathways triggered by mitomycins interstrand crosslinks
Funded at John Jay College of Criminal Justice · NIH-11348258 · Data updated 2026-11-12
Researchers will study how different mitomycin-induced DNA crosslinks trigger cellular signals that lead to cell death or cell cycle arrest, especially when the tumor suppressor p53 is not working.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | John Jay College of Criminal Justice NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $162,658 |
| NIH project number | 5R16GM149514-04 |
| Project ID | NIH-11348258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancer whose tumors may be treated with mitomycins or whose tumor biology involves p53 signaling pathways.
✕Less likely to help
Patients whose cancers do not rely on the studied pathways or who cannot tolerate mitomycin-type drugs may see no direct benefit.
What this research studies
This project looks at how three forms of mitomycin-induced DNA crosslinks affect cancer cells. It will examine the cellular pathways activated by these crosslinks and how the structure of each crosslink changes the signaling that leads to death or growth arrest. The work uses mitomycin C, its derivative DMC, and a novel MC-derivative MC-Lex to compare their effects. Findings could reveal why some cancers respond differently to these drugs and point toward more effective treatments.
Why it matters
Potential benefit: If successful, the research could improve understanding of how certain chemo drugs kill cancer cells, potentially guiding better use of mitomycins in patients.
How similar studies have gone: Previous work shows that different ICLs trigger distinct cellular responses, supporting a follow-on line of investigation.
Where this research is happening
-
John Jay College of Criminal Justice
New York, United States Active
Researchers
- Principal investigator: Champeil, Elise — John Jay College of Criminal Justice
- Study coordinator: Champeil, Elise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.