Mitochondria's role in regulating RNA modifications
Mitochondrial 2-hydroxyglutarate dehydrogenases modulate the cellular epitranscriptome
This study is looking at how tiny parts of our cells called mitochondria affect the way RNA is changed in our bodies, which can influence how our genes work, and it hopes to help patients understand how keeping their mitochondria healthy might improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10755263 on NIH RePORTER |
What this research studies
This research investigates how mitochondria influence the chemical modifications of RNA, specifically focusing on the metabolites 2-hydroxyglutarate and alpha-ketoglutarate. These metabolites are produced in mitochondria and are believed to affect the activity of enzymes that modify RNA, which in turn can impact gene expression. By understanding these mechanisms, the research aims to uncover how mitochondrial function is linked to various diseases through the regulation of RNA methylation. Patients may benefit from insights into how mitochondrial health affects their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction or diseases associated with RNA methylation dysregulation.
Not a fit: Patients with conditions unrelated to mitochondrial function or RNA modifications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting mitochondrial function to improve gene regulation in diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of mitochondrial metabolites in cellular processes, suggesting potential for success in this area.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Aguiar, Ricardo C — University of Texas Hlth Science Center
- Study coordinator: Aguiar, Ricardo C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.