Mitochondrial stress in Alzheimer's and other brain diseases
Mitochondrial Integrated Stress Response in Neurological Diseases
Looking at how problems in mitochondria — the cell's powerhouses — affect people with Alzheimer's and related neurodegenerative conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11330509 on NIH RePORTER |
What this research studies
This research focuses on how mitochondrial dysfunction rewires brain-cell metabolism and triggers a cellular stress response that can damage neurons and glia. The team studies molecular signals of the mitochondrial integrated stress response using lab models and analyses of disease-related tissues and samples. By tracing how these changes unfold in brain cells, researchers hope to identify points where interventions could protect cells. Findings will guide later efforts to develop therapies or biomarkers for Alzheimer's and similar conditions.
Who could benefit from this research
Good fit: People diagnosed with Alzheimer's disease or other neurodegenerative conditions, or individuals willing to donate blood or tissue samples for research, are the most relevant candidates for this work.
Not a fit: Patients seeking immediate new treatments or those without mitochondrial-linked neurodegeneration are unlikely to receive direct clinical benefit from this basic research right away.
Why it matters
Potential benefit: If successful, the work could point to new targets for treatments that protect brain cells and slow neurodegeneration in Alzheimer's and related disorders.
How similar studies have performed: Previous laboratory studies have linked mitochondrial problems to neurodegeneration and provided strong basic evidence, but translating these findings into effective patient treatments remains largely unproven.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Manfredi, Giovanni — Weill Medical Coll of Cornell Univ
- Study coordinator: Manfredi, Giovanni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.