Mitochondrial shape and function in health and disease
Regulation of mitochondrial morphology and functional versatility
['FUNDING_OTHER'] · NEW YORK UNIVERSITY · NIH-11089565
This work looks at how the shape of mitochondria affects their energy production and cell survival, with implications for people with cancer, heart disease, and other conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11089565 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers are examining the molecular machines (like OPA1 and the MICOS complex) that sculpt the inner structure of mitochondria and keep them working. They will manipulate these proteins in cells and model systems, take detailed images of mitochondrial architecture, and measure energy production, DNA stability, and sensitivity to cell death. By linking specific structural changes to functional problems, the team hopes to explain why mitochondria fail in cancers, cardiovascular disease, and neurodegeneration. The findings are intended to point to new targets for future therapies rather than test treatments in people right now.
Who could benefit from this research
Good fit: This is a laboratory-focused grant that does not recruit patients, though its results are most relevant to people with cancers, cardiovascular disease, mitochondrial disorders, or related conditions.
Not a fit: People whose illnesses are unrelated to mitochondrial dysfunction are unlikely to see a direct short-term benefit from this project.
Why it matters
Potential benefit: If successful, the work could reveal new molecular targets to protect or restore mitochondrial function and guide development of therapies for cancer, heart disease, and related disorders.
How similar studies have performed: Prior basic research has shown OPA1 and MICOS affect mitochondrial shape and function, but turning those findings into treatments remains an early and active area of work.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AYDIN, HALIL — NEW YORK UNIVERSITY
- Study coordinator: AYDIN, HALIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiovascular Diseases