Mitochondrial pp60Src and metabolism in kids with congenital heart disease–related lung vessel disease
Official title: Mitochondrial pp60Src and cellular metabolism in pulmonary vascular disease associated with CHD
Funded at Florida International University · NIH-11401972 · Data updated 2026-11-12
A child-focused project explores how tiny energy factories in cells influence lung blood vessels in kids with congenital heart defects.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | August 10, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $371,205 |
| NIH project number | 5P01HL146369-08 |
| Project ID | NIH-11401972 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with congenital heart defects that affect blood flow to the lungs and are at risk for pulmonary vascular disease.
✕Less likely to help
Children without pulmonary vascular disease risk factors or those not eligible for sample-based analyses may see limited direct benefit.
What this research studies
This project looks at how changes in cellular metabolism and specific mitochondrial enzymes affect the lung vessels in children with congenital heart defects. It builds on prior findings showing that a protein called pp60Src inside mitochondria can alter energy production and vascular cell function, which may drive pulmonary vascular disease. The research aims to map these connections and identify targets to prevent or lessen lung vessel problems in affected children. Results could lead to new approaches to monitor and treat pulmonary vascular disease early in life. The study involves pediatric biology and may use patient-derived cells or samples to understand disease mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict, monitor, and treat pulmonary vascular disease in children with congenital heart defects.
How similar studies have gone: Previous work has shown that mitochondrial signaling can influence vascular function, supporting potential benefit but translations to patients are still developing.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Black, Stephen M — Florida International University
- Study coordinator: Black, Stephen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.