Mitochondrial Imaging, PTM Analysis & Metabolic Testing Core for pediatric projects
Official title: Mitochondrial Imaging, PTM Analysis & Metabolism Core
Funded at Florida International University · NIH-11401954 · Data updated 2026-11-12
A core grant helps researchers study how mitochondria work, modify proteins, and metabolize substances in children and animal models to understand congenital heart disease and related biology.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | August 10, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $371,205 |
| NIH project number | 5P01HL146369-08 |
| Project ID | NIH-11401954 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include children with congenital heart disease or related biological samples, and model organisms or cell systems used in pediatric mitochondrial research.
✕Less likely to help
Non-pediatric patients or samples not related to heart disease or mitochondrial function may not benefit directly.
What this research studies
This core provides high-resolution imaging of mitochondria, analysis of protein modifications, and metabolic testing to support three pediatric research projects. It includes measuring mitochondrial function, bioenergetics, PTMs with mass spectrometry, and metabolomics in cells, tissues, and plasma from animals and children with congenital heart conditions. The services aim to map how mitochondrial changes relate to disease, using patient-relevant samples and animal models to drive discoveries that could inform new therapies.
Why it matters
Potential benefit: If successful, the core could accelerate understanding of mitochondrial dysfunction in pediatric heart disease, potentially guiding better treatments.
How similar studies have gone: Previous studies show that detailed mitochondrial imaging and PTM/metabolomic profiling can reveal disease-associated changes and guide targeted interventions.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Black, Stephen M — Florida International University
- Study coordinator: Black, Stephen M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.