Mitochondrial gene regulation in CNS development and its links to Alzheimer’s-related conditions
Official title: Mitochondrial gene regulation in CNS development
Funded at State University of New York at Buffalo · NIH-11450225 · Data updated 2026-11-12
A research team is studying how brain energy production in mitochondria is controlled during brain development and how this relates to Alzheimer’s disease and related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $645,070 |
| NIH project number | 1R01NS146474-01A1 |
| Project ID | NIH-11450225 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at risk for Alzheimer’s disease dementia or related neurodevelopmental disorders, in the context of future translational research opportunities.
✕Less likely to help
Patients without Alzheimer’s disease dementia or related neurodevelopmental conditions may not directly benefit from this basic mechanistic study.
What this research studies
This project will look at how genes in mitochondria are controlled during brain development and how that control affects neuron growth and brain wiring. It will focus on the forebrain and a key regulator called Foxg1 to see how mitochondrial activity, cell division, and neuron formation are connected. The aim is to uncover mechanisms that may contribute to Alzheimer’s disease and other neurodevelopmental disorders. The findings could point to new targets for therapies that support healthy brain energy use. Researchers will use studies in development models to understand potential disease pathways.
Why it matters
Potential benefit: If successful, the research could reveal new targets to support brain energy production and potentially slow or modify progression of Alzheimer’s-related conditions.
How similar studies have gone: Previous work has linked mitochondrial dysfunction to neurodegenerative diseases, with growing evidence that developmental processes influence disease risk.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Lee, Soo-Kyung — State University of New York at Buffalo
- Study coordinator: Lee, Soo-Kyung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.