Mitochondrial complex I function in people with schizophrenia
In vivo assessment of the mitochondrial complex I in subjects with schizophrenia
Researchers will measure how a key energy-producing part of brain cells (mitochondrial complex I) works in people with schizophrenia and how that relates to thinking problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11229630 on NIH RePORTER |
What this research studies
If you join, researchers will use noninvasive brain imaging and recordings of brain activity, and may collect blood samples to look at mitochondrial complex I function in the brain. They will ask participants to perform thinking tasks while measuring gamma-range brain activity in areas important for memory and attention. The team will compare the findings in people with schizophrenia to expected patterns to see whether reduced cellular energy links to cognitive symptoms. This is an early-stage, exploratory effort aimed at understanding the brain biology behind thinking difficulties.
Who could benefit from this research
Good fit: Adults with a diagnosis of schizophrenia who have cognitive symptoms and can attend study visits at NYU would be ideal candidates.
Not a fit: People without schizophrenia, those who are medically unstable, cannot undergo brain imaging, or cannot travel to New York are unlikely to benefit from participating.
Why it matters
Potential benefit: If successful, the findings could point to new ways to treat or prevent thinking problems in schizophrenia.
How similar studies have performed: Previous postmortem and laboratory studies suggest mitochondrial issues in schizophrenia, but direct in vivo measurement of complex I in living patients is limited and relatively novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Frankle, William G — New York University School of Medicine
- Study coordinator: Frankle, William G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.