Mitochondria-rich particles to boost heart cell energy
Mitochondria-rich microvesicles for restoration of intracellular bioenergetics
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11324295
This project tests tiny, mitochondria-rich packets from stem-cell-derived heart cells to help heart muscle cells make more energy for people with heart failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11324295 on ClinicalTrials.gov |
What this research studies
Researchers are using heart cells made from induced pluripotent stem cells that release mitochondria-rich extracellular vesicles (M-EVs). In laboratory and preclinical work, these M-EVs can deliver mitochondria to injured heart cells and increase their ATP production. The team aims to turn this mitochondrial transfer into a therapy to repair injured heart muscle and address the energy imbalance seen in heart failure and cardiomyopathies. The research is being conducted at Stanford and could guide future clinical trials if results remain promising.
Who could benefit from this research
Good fit: People with heart failure or cardiomyopathy (including hypertrophic, dilated, or ischemic types) would be the most likely candidates for future therapies based on this work.
Not a fit: People without heart muscle disease or those seeking immediate, already approved treatments are unlikely to receive direct benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this approach could restore energy production in failing heart cells and potentially improve symptoms and outcomes for people with heart failure.
How similar studies have performed: Stem-cell-derived cell therapies and their secreted factors have shown promise in animal studies, but using mitochondria-rich vesicles is a novel, early-stage approach with limited human data.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, PHILLIP CHUNG-MING — STANFORD UNIVERSITY
- Study coordinator: YANG, PHILLIP CHUNG-MING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.