Minimizing heart damage after a heart attack with targeted PKC inhibitors

Who could benefit from this research

What this research studies

This program focuses on refining two drug candidates, YT-002 and YT-004, that specifically target PKC enzymes in the heart to limit damage after a heart attack. Researchers will improve how the drugs behave in the body, study long-term safety and effectiveness in pig models, and prepare data to support an initial human trial. They will optimize formulations for stable delivery to the heart, map how the drugs are absorbed and cleared, and measure sustained benefits on heart tissue and function. The project uses advanced modeling to link drug dose to outcomes and to define the most promising therapeutic window.

Why it matters

Where this research is happening

• Young Therapeutics, LLC
  Philadelphia, United States Active

Researchers

• Principal investigator: Argentieri, Thomas — Young Therapeutics, LLC
• Study coordinator: Argentieri, Thomas

Related research

Other NIH-funded projects on the same topics.

• Anti-inflammatory signaling of a key protein in heart attack recovery

  A study in people who have had a heart attack is exploring how a macrophage protein called Tristetraprolin may reduce inflammation and help protect heart tissue.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11539056

• Targeting RIPK3 to reduce heart damage after a heart attack

  This grant studies a specific cell-death pathway (RIPK3) to protect the heart after a heart attack, with the goal of reducing damage and improving recovery.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11450795

• mRNA lipid nanoparticles to help heart attack patients grow healthier blood vessels

  A heart-attack study tests a new treatment that uses messenger RNA delivery with tiny fat bubbles to promote normal blood vessel growth in damaged heart tissue.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11450514

• Targeted nanotherapy to calm inflammation, grow new blood vessels, and prevent scarring after a heart attack

  A new treatment approach uses engineered secretions from immune cells delivered early after a heart attack to reduce inflammation, promote blood vessel growth, and limit scarring to protect heart function.

  NIH research Washington University · Saint Louis, United States · NIH-11432693

• Why heart attacks and strokes affect people differently across places and races

  This project follows adults across the U.S. to see how lifelong social and neighborhood factors shape heart attacks, heart failure, and recovery, with attention to Black adults and regions with high disease rates.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11418586

• Real-time multi-lead ECG from wearables to help detect heart attacks early

  A new AI-based approach uses everyday wearable sensors to turn simple PPG signals into multi-lead ECG data to monitor for heart attacks in real time, even outside the clinic.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11417336

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.