Mindfulness plus internal-sensation training (ITEM) for anxiety sensitivity

Interoceptive Training Enhanced Mindfulness (ITEM): Acceptability and Measurement

NIH-funded research Veterans Medical Research Fdn/san Diego · NIH-11302677

A new program that combines mindfulness with controlled practice of noticing internal body sensations to help Veterans who fear anxiety-related physical symptoms.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionVeterans Medical Research Fdn/san Diego NIH-funded
Lab location1 site (San Diego, United States)
Project IDNIH-11302677 on NIH RePORTER

What this research studies

You would learn mindfulness skills together with guided practice of feeling and tolerating uncomfortable internal sensations (like a racing heart or breathlessness). First, a small group of 12 Veterans will try the program and give feedback so the team can improve it. After refinement, 48 Veterans will be randomly assigned to get either the ITEM program or standard interoceptive exposure across six one-on-one sessions. The project also develops a set of ways to measure how people respond, including questionnaires and other tests.

Who could benefit from this research

Good fit: Ideal candidates are adult Veterans with high anxiety sensitivity or strong fear of arousal-related bodily symptoms, including those with anxiety, trauma-related, or somatic symptom concerns.

Not a fit: People without elevated anxiety sensitivity or those with conditions that make exposure to bodily sensations unsafe (e.g., unstable cardiac disease) may not benefit or be eligible.

Why it matters

Potential benefit: If successful, the program could make exposure-based treatments easier to tolerate and reduce fear of bodily symptoms that drive anxiety and related problems.

How similar studies have performed: Traditional interoceptive exposure and mindfulness each show benefit for anxiety, but combining them in this hybrid approach is new and relatively untested.

Where this research is happening

San Diego, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.