Mindful self-compassion to reduce pain interference in adults with osteogenesis imperfecta

Project 2: MSC

NIH-funded research Baylor College of Medicine · NIH-11173434

An 8-week online mindful self-compassion program is offered to adults with osteogenesis imperfecta to help reduce how much chronic pain gets in the way of daily life, compared with relaxation training.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionBaylor College of Medicine NIH-funded
Lab location1 site (Houston, United States)
Project IDNIH-11173434 on NIH RePORTER

What this research studies

You would be invited to join an 8-week virtual mindful self-compassion (MSC) program led by instructors who have lived experience with osteogenesis imperfecta (OI). Participants are randomly assigned to either the MSC program or a relaxation training (RT) control and complete the program online. The team measures pain interference one month after treatment and also tracks pain intensity, catastrophizing, quality of life, and physical functioning to understand how the program helps. The trial builds on pilot data showing the virtual MSC is feasible and acceptable for adults with OI.

Who could benefit from this research

Good fit: Adults (age 21 and over) with osteogenesis imperfecta who experience chronic pain and can attend scheduled online sessions are the ideal candidates.

Not a fit: People without OI, those with only short-term acute pain, or individuals unable to participate in virtual sessions (for example due to severe cognitive impairment or lack of internet access) are unlikely to benefit from this program.

Why it matters

Potential benefit: If successful, the program could help adults with OI feel less limited by chronic pain and improve daily function and quality of life without relying on stronger pain medications.

How similar studies have performed: Mindful self-compassion programs have reduced pain interference in other chronic pain groups and pilot data in OI show feasibility, though large randomized trials in OI remain limited.

Where this research is happening

Houston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.