Milrinone to prevent heart and breathing problems after PDA closure in extremely premature infants
2/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) - DCC Resubmission
This project tests whether giving milrinone around the time of PDA surgery helps prevent dangerous heart and lung problems in extremely premature newborns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project ID | NIH-11124709 on NIH RePORTER |
What this research studies
If your baby is born extremely premature and needs surgical closure of a patent ductus arteriosus (PDA), this effort would randomly assign babies to receive milrinone or a masked comparison around the time of surgery. Care teams at multiple neonatal intensive care units in a research network would follow standardized treatment and monitoring plans. The study will track how often babies develop Post-Ligation Cardiac Syndrome (severe instability after PDA closure), other clinical outcomes, and any side effects. Data will be collected and monitored centrally to compare safety and short-term outcomes between groups.
Who could benefit from this research
Good fit: Ideal candidates are extremely premature infants who require surgical ligation of a patent ductus arteriosus and meet the study's clinical criteria.
Not a fit: Babies who are not extremely premature, who do not need PDA surgery, or who have medical reasons they cannot receive milrinone are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this could lower the chance of Post-Ligation Cardiac Syndrome and improve short-term heart and lung stability after PDA surgery in extremely preterm infants.
How similar studies have performed: Preliminary and observational data suggest milrinone may reduce PLCS risk, but no randomized controlled trials have yet tested this preventive approach.
Where this research is happening
Research Triangle Park, United States
- Research Triangle Institute — Research Triangle Park, United States (Active)
Researchers
- Principal investigator: Das, Abhik — Research Triangle Institute
- Study coordinator: Das, Abhik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.