NIH-funded research R01 grant

Milk-TOT: Whole vs. 1% Milk and Toddler Weight and Health

Official title: Milk Type in Toddlers (Milk-TOT) Study: Impact of Whole versus Low-fat Milk on Child Adiposity, Health and Development

Funded at Univ of Calif/div/agriculture/nat/resour · NIH-11369879 · Data updated 2026-11-12

A year-long study will compare whole milk to 1% milk in 2-year-olds to see how milk fat type affects body fat, growth, and health.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of Calif/div/agriculture/nat/resour
NIH-funded
Lab location1 site (Oakland, United States)
Project startSeptember 15, 2023
Project endJune 30, 2028
Funding year2026
Award (this year)$674,856
NIH project number5R01DK131217-04
Project IDNIH-11369879 on NIH RePORTER

Who could benefit from this research

Could help

Parents of healthy toddlers around age 2 who have recently switched to cow’s milk.

Less likely to help

Children with special health needs or milk allergies/intolerances may not benefit from a milk-fat comparison.

What this research studies

This study will enroll about 625 toddlers who have just transitioned to cow’s milk and randomly assign them to drink either whole milk or 1% milk for 12 months. Researchers will track adiposity using waist-to-height ratio and other health and development measures to understand how milk fat type impacts early obesity risk and overall growth. The trial is designed to inform parents and clinicians about which milk type supports healthier body composition during a critical period of development.

Why it matters

Potential benefit: If successful, the findings could guide recommendations on milk choices to support healthier weight and development in early childhood.

How similar studies have gone: Previous observational data show associations but randomized trials like Milk-TOT are needed to establish causality.

Where this research is happening

  • Univ of Calif/div/agriculture/nat/resour
    Oakland, United States
    Active

Researchers

  • Principal investigator: Ritchie, Lorrene D — Univ of Calif/div/agriculture/nat/resour
  • Study coordinator: Ritchie, Lorrene D

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.