Microglia-driven brain network changes after traumatic brain injury
Satellite Microglia: Role in Maladaptive Network Remodeling after TBI
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11245719
This research looks at whether certain immune cells in the brain (microglia) change how brain cells communicate after a traumatic brain injury and how that affects thinking and behavior.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11245719 on ClinicalTrials.gov |
What this research studies
This project uses genetically modified mice to follow microglia that sit next to neurons after traumatic brain injury and measures how they affect brain activity, learning, and behavior. Researchers will examine whether these 'satellite' microglia lose a receptor called P2Y12 after injury and whether that change makes brain networks more excitable. The team will combine cell imaging, recordings of brain electrical activity, and behavioral tests to link cellular changes to cognitive problems. The goal is to identify cellular mechanisms that could point to future treatments for people with chronic problems after TBI.
Who could benefit from this research
Good fit: People with a history of traumatic brain injury who have ongoing memory, learning, or behavioral difficulties would be most relevant to this line of research.
Not a fit: People without TBI, those whose symptoms are explained by non-brain causes, or those seeking immediate clinical treatments are unlikely to benefit directly from this preclinical animal research.
Why it matters
Potential benefit: If successful, this work could point to a new cellular target (microglial P2Y12 signaling) to help prevent or reduce long-term cognitive and behavioral problems after TBI.
How similar studies have performed: Prior animal studies, including the investigators' preliminary data, suggest microglia affect neuronal excitability, but translating these findings into human therapies is still largely untested.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOLAN, AMBER L — UNIVERSITY OF WASHINGTON
- Study coordinator: NOLAN, AMBER L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.