Microglia and early brain development in autism
Neuroimmunological insights into brain development and dysfunction: an integrative approach focused on microglial dynamics
This work looks at how immune cells in the brain called microglia and environmental factors influence early brain wiring linked to autism in young children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11062706 on NIH RePORTER |
What this research studies
The team uses advanced lab tools—including high-resolution two-photon imaging, genetic CRISPR screens, and cell and animal models—to watch how microglia interact with developing brain circuits. They will change specific genes and environmental conditions associated with autism to see which ones disrupt circuit wiring. By combining live imaging with molecular and genetic approaches, they aim to identify the microglial behaviors and genes that drive developmental problems. Those discoveries are intended to point toward biological targets for future treatments or preventive strategies.
Who could benefit from this research
Good fit: Families of young children (approximately 0–11 years) with autism spectrum disorder or related developmental concerns would be most relevant to follow this work or to take part in future sample-collection efforts.
Not a fit: People seeking immediate clinical treatments or adults without neurodevelopmental disorders are unlikely to receive direct benefit from this laboratory-focused research.
Why it matters
Potential benefit: If successful, this work could reveal new biological targets and strategies for preventing or treating autism-related brain wiring problems.
How similar studies have performed: Animal and cellular studies have previously linked microglial dysfunction to autism-like changes, but moving those findings into effective human therapies is still largely unproven.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Cheadle, Lucas M — Cold Spring Harbor Laboratory
- Study coordinator: Cheadle, Lucas M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.