Michigan Pediatric Cancer Proteogenomics Center
Michigan Center for Translational Cancer Proteogenomics
This project will combine protein and genetic data to find new treatment targets for children and young adults with cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11332165 on NIH RePORTER |
What this research studies
Researchers at the University of Michigan will build 'ProKids', a harmonized pediatric proteogenomic database using tumor and germline data from the Kids First cohort and other childhood cancer datasets. They will compare tumor proteins and genetic changes across different pediatric cancers and against adult cancers to spot unique molecular features and potential drug targets, with special focus on cell-surface markers for immunotherapy. The team will link inherited genetic variants to protein-level changes to help explain predisposition and outcomes, and will examine protein modifications and developmental signaling in tumors to uncover actionable vulnerabilities.
Who could benefit from this research
Good fit: Children and young adults with pediatric cancers—especially those with hematologic malignancies—who have tumor and germline samples available or who are enrolled in Kids First or similar pediatric cancer research programs.
Not a fit: Patients without available tumor or genetic samples, or those needing immediate clinical treatment, are unlikely to receive direct benefit from this data-focused project.
Why it matters
Potential benefit: If successful, this work could reveal new drug or immunotherapy targets and clarify inherited risks, helping to speed the development of better treatments for children with cancer.
How similar studies have performed: Proteogenomic efforts have produced important findings in adult cancers through programs like CPTAC, but broad application to pediatric cancers is newer and less established.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Nesvizhskii, Alexey I — University of Michigan at Ann Arbor
- Study coordinator: Nesvizhskii, Alexey I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.