Michigan Drug‑Related Liver Injury Network
Michigan Hepatotoxicity Clinical Research Network Renewal
This project follows people who develop liver injury from medicines or supplements to find genetic and blood-based signs that help pinpoint causes and predict recovery.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11169087 on NIH RePORTER |
What this research studies
If you join, researchers will enroll people with likely drug- or supplement-related liver injury and collect medical records, blood, and other samples. They will use electronic medical record search tools and partner hospitals to increase enrollment, with a focus on including more people from diverse ethnic backgrounds. Lab work will include genetic, RNA, and metabolite testing and making patient-derived liver organoids to see how individual livers respond to drugs in high-throughput plates and on a liver chip. The team will link lab results to real patient cases to improve how causes and outcomes are understood.
Who could benefit from this research
Good fit: Ideal candidates are people with a recent or well-documented suspected drug- or supplement-related liver injury who can provide medical records and blood samples and agree to follow-up.
Not a fit: People without suspected drug- or supplement-related liver injury or whose liver disease is clearly from other causes are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this work could help doctors identify which medicine caused a patient's liver injury and better predict who is at higher risk of severe outcomes.
How similar studies have performed: Earlier DILIN prospective and retrospective studies have already identified genetic risk factors and improved diagnostic tools, so this renewal builds on established successes.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Fontana, Robert J — University of Michigan at Ann Arbor
- Study coordinator: Fontana, Robert J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.