Methylation and metabolism signals linked to lung function in kids with asthma
Official title: Methylomic and metabolomic determinants of Lung Function in Asthmatics
Funded at Rutgers Biomedical and Health Sciences · NIH-11628962 · Data updated 2026-11-12
This grant looks at how genes, environment, and small chemical changes in the body together affect how lung function changes over time in children with asthma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $109,900 |
| NIH project number | 3R00HL159234-05S1 |
| Project ID | NIH-11628962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with asthma, particularly those who have varying lung function trajectories.
✕Less likely to help
Children without asthma or those not participating in pediatric multi-omic biospecimen studies may not benefit directly.
What this research studies
Researchers will study how DNA methylation and metabolic profiles interact with known asthma genes to influence lung function trajectories in children. By analyzing data from large pediatric cohorts, they aim to identify pathways in Wnt, Hippo, and sphingolipid signaling that connect environmental exposures to lung health. The project uses advanced bioinformatics to integrate multi-omic data and spot converging evidence for mechanisms driving asthma progression. Findings could point to biomarkers and targets for improving lung outcomes in pediatric asthma.
Why it matters
Potential benefit: If successful, the work could improve understanding of why some children with asthma lose lung function and help guide personalized prevention or treatment strategies.
How similar studies have gone: Previous studies have linked methylation or metabolomics to lung function separately; this project combines both to seek stronger, converging evidence.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Kachroo, Priyadarshini — Rutgers Biomedical and Health Sciences
- Study coordinator: Kachroo, Priyadarshini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.