Metformin for Preventing Alzheimer's Dementia
Metformin in Alzheimer's dementia Prevention (MAP)
This project explores whether the medication metformin can help prevent memory decline in people at risk for Alzheimer's dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10851676 on NIH RePORTER |
What this research studies
This large-scale clinical trial is testing if metformin, a common medication, can prevent cognitive decline in individuals who are at risk for Alzheimer's dementia. Participants will receive either metformin or a placebo to see if the medication can slow down memory problems. This work builds on earlier promising results from a smaller study, which suggested that metformin might improve memory in certain individuals. The current trial uses a long-acting form of metformin, which is typically better tolerated, and involves multiple locations to gather more comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates are individuals at risk for Alzheimer's dementia who do not have diabetes and may be overweight or obese.
Not a fit: Patients who already have advanced Alzheimer's dementia or those not at risk for the condition may not receive benefit from this preventative approach.
Why it matters
Potential benefit: If successful, this medication could offer a new way to prevent or delay the onset of Alzheimer's dementia.
How similar studies have performed: A previous small pilot study showed that metformin improved memory recall in participants compared to a placebo.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Luchsinger, Jose Alejandro — Columbia University Health Sciences
- Study coordinator: Luchsinger, Jose Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.