Metabolite biomarkers to spot and classify osteoarthritis early
Metabolomic Profiling to Identify Candidate Biomarker Profiles and Molecular Endotypes for Osteoarthritis
Looks at whether patterns of small molecules in joint fluid and blood can spot and classify osteoarthritis earlier in people with joint pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project ID | NIH-11145222 on NIH RePORTER |
What this research studies
Researchers will collect synovial (joint) fluid and blood plasma from people with different degrees of osteoarthritis and analyze small-molecule (metabolite) patterns using advanced metabolomics techniques. They will compare metabolite profiles to clinical measures and imaging to find panels that track disease grade and distinct molecular subtypes (endotypes). The goal is to identify signatures that reveal early-stage OA or different biological forms of the disease. These findings would be used to guide future tests that could be done from a blood draw or joint sample.
Who could benefit from this research
Good fit: Adults with suspected or diagnosed knee or hip osteoarthritis who are willing to provide blood and, when clinically appropriate, joint (synovial) fluid samples.
Not a fit: People without osteoarthritis, those with other inflammatory joint diseases, or anyone unwilling or unable to provide blood or joint fluid samples are unlikely to benefit from participation.
Why it matters
Potential benefit: Could enable earlier diagnosis and more personalized treatment or monitoring for people with osteoarthritis.
How similar studies have performed: Metabolomics for osteoarthritis is a promising and active area of research with some supportive association studies, but no metabolite panel has yet been validated for routine clinical use.
Where this research is happening
Bozeman, United States
- Montana State University - Bozeman — Bozeman, United States (Active)
Researchers
- Principal investigator: June, Ronald Kent — Montana State University - Bozeman
- Study coordinator: June, Ronald Kent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.