Metabolic changes linked to reactive oxygen and nitrogen species in cardiovascular health
Official title: Metabolic rewiring coupled to the production of reactive oxygen and nitrogen species (RONS)
Funded at Morgridge Institute for Research, INC. · NIH-11335740 · Data updated 2026-11-12
A study aims to understand how immune and blood vessel cells switch their metabolism to produce reactive oxygen and nitrogen species, which play roles in inflammation and heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morgridge Institute for Research, INC. NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $426,280 |
| NIH project number | 5R35GM147014-05 |
| Project ID | NIH-11335740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with cardiovascular conditions characterized by inflammation and altered neutrophil function, or samples from such patients may be studied.
✕Less likely to help
Healthy individuals without cardiovascular inflammation may have limited direct benefit.
What this research studies
This project explores how cells adjust their metabolism to support the production of reactive oxygen and nitrogen species, which are important for signaling and defense but can contribute to disease. Researchers will examine how NADPH supply and redox balance are managed during NOX and NOS activity, especially in neutrophils. They plan to uncover the molecular steps that enable a rapid metabolic shift from glycolysis to a high-NADPH metabolism. The goal is to connect these metabolic changes to cardiovascular diseases and related inflammatory conditions.
Why it matters
Potential benefit: If successful, the findings could reveal new targets to modulate harmful inflammation and improve cardiovascular health.
How similar studies have gone: Previous work showed NOX/NOS-driven metabolism changes in immune cells; this project extends that to broader pathways relevant to cardiovascular disease.
Where this research is happening
-
Morgridge Institute for Research, INC.
Madison, United States Active
Researchers
- Principal investigator: Fan, Jing — Morgridge Institute for Research, INC.
- Study coordinator: Fan, Jing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.