Metabolic causes of heart failure in South Asian adults
Metabolic effects and mechanisms for heart failure in South Asians
This project looks at how metabolism and body fat patterns relate to early heart failure and HFpEF in South Asian adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11091662 on NIH RePORTER |
What this research studies
You would be part of the MASALA group of South Asian adults whose health has been measured over time to learn about early heart failure and HFpEF. Researchers will repeat metabolic tests, scans that show fat around organs and in the liver, and heart function checks in about 850 participants. They will compare results to the multi-ethnic MESA study to see which metabolic patterns are specific to South Asians. The team aims to connect diabetes, abdominal or ectopic fat, and other metabolic issues to the biological causes of HFpEF.
Who could benefit from this research
Good fit: Ideal candidates are South Asian adults (age 21+) with metabolic risk factors such as diabetes, obesity, or high abdominal/ectopic fat who can attend visits at participating U.S. centers.
Not a fit: People who are not South Asian, whose heart failure is driven by non-metabolic causes, or who already have advanced reduced-ejection-fraction heart failure may not receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this work could point to new ways to detect, prevent, or target treatments for HFpEF in South Asian adults.
How similar studies have performed: Other research has linked ectopic fat and metabolic disease to heart problems, but treatments that clearly improve outcomes for HFpEF are lacking and focused studies in South Asians are relatively new.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Kanaya, Alka M. — University of California, San Francisco
- Study coordinator: Kanaya, Alka M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.