Mental health and emotion regulation in autistic adults

Mental Health in Autistic Adults: An RDoC Approach

NIH-funded research University of Pittsburgh at Pittsburgh · NIH-11121008

This project will track emotions, behavior, and body-signals over two weeks in autistic and non-autistic adults to learn what precedes suicidal thoughts, self-injury, and impulsive aggression.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Pittsburgh at Pittsburgh NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-11121008 on NIH RePORTER

What this research studies

You would wear a small ambulatory sensor and answer short smartphone surveys for 14 days while researchers continuously record heart-rate-related signals to capture sympathetic and parasympathetic activity. The team will enroll about 200 autistic adults and 100 non-autistic adults, with extra enrollment of people who have had recent suicidal thoughts or self-injury. Data will combine your momentary self-reports, observable behavior, and physiological signals to see how emotion dysregulation shows up across everyday contexts. The goal is to understand which patterns in daily life raise short-term risk for crises so future supports can be timed and targeted.

Who could benefit from this research

Good fit: Autistic adults age 21 and older (including older adults) who can consent, use a smartphone for brief surveys, and wear a small ambulatory sensor—particularly those with recent suicidal thoughts, self-injury, or impulsive aggression.

Not a fit: People younger than 21, those unable to use a smartphone or wear the sensor, or those without emotion-related difficulties may not be eligible or likely to get direct benefit from this project.

Why it matters

Potential benefit: If successful, this work could help identify real-life warning signs and timing for interventions to prevent suicidal behavior and self-injury in autistic adults.

How similar studies have performed: Similar ecological momentary assessment and wearable-monitoring approaches have shown promise in other psychiatric groups, but applying them specifically to autistic adults is relatively new.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.