Memory natural killer cells that could protect adults against many flu strains
Heterosubtypic immunity to influenza virus mediated by MHC-E-restricted memory NK cells
Researchers are studying whether special memory natural killer (NK) cells that target shared parts of the influenza virus can help adults fight a wide range of flu strains.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11161398 on NIH RePORTER |
What this research studies
This Duke-led project looks for memory-like NK cells in adults that recognize conserved influenza antigens. Researchers collect adult blood samples, isolate NK cells, and use lab tests to measure how these cells respond to different flu pieces. The team will study how the human HLA-E (MHC-E) molecule helps activate these NK cells and connect human findings with prior animal and primate work to understand potential broad protection.
Who could benefit from this research
Good fit: Adults aged 21 and older who can give blood samples and are willing to share their influenza vaccination or infection history would be the ideal candidates.
Not a fit: People under 21, those unable to provide blood samples, or individuals with severe immune disorders may not be eligible or receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this work could lead to vaccines or immune therapies that protect adults against many different flu strains for longer periods.
How similar studies have performed: Prior animal and early human studies have found memory-like NK responses to viruses, but applying these responses for broad influenza protection is a novel approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Jost, Stephanie — Duke University
- Study coordinator: Jost, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.