Membrane traffic to lysosomes in yeast and humans
Official title: Membrane trafficking to lysosomes
Funded at University of Colorado · NIH-11524927 · Data updated 2026-11-12
This grant supports research to understand how cells send materials to lysosomes for recycling, using budding yeast to uncover mechanisms that are also important in human health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | May 4, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $14,365 |
| NIH project number | 3R35GM149202-04S1 |
| Project ID | NIH-11524927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with conditions linked to lysosome or trafficking pathway dysfunction or healthy volunteers contributing samples; however, this project is primarily basic biology in yeast.
✕Less likely to help
Direct patient benefits are not guaranteed during this basic research phase and no specific clinical trial is described.
What this research studies
The project uses baker’s yeast as a model to study how membrane trafficking delivers materials to lysosomes, which are key recycling centers in cells. It aims to uncover the rules that control trafficking of cell-surface receptors to lysosomes, including how ubiquitin and pH affect this process. Findings could reveal fundamental clues about how cells regulate their waste processing and respond to pathogens. The work spans basic biology with potential implications for human diseases linked to trafficking defects.
Why it matters
Potential benefit: Better understanding of lysosome function could inform future therapies for diseases caused by trafficking defects.
How similar studies have gone: Similar yeast-based trafficking studies have advanced our understanding of lysosome biology, with conceptual relevance to human disease.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Odorizzi, Charles G — University of Colorado
- Study coordinator: Odorizzi, Charles G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.