Membrane chemistry behind aging and Alzheimer’s disease
Official title: Membrane reconstitution approach for the investigation of lipid peroxidation mechanisms and its pathological effects
Funded at Colorado State University · NIH-11396385 · Data updated 2026-11-12
Researchers are testing how lipid peroxidation in cell membranes happens and how it relates to aging and Alzheimer’s disease, using a new membrane-based test.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | September 21, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $372,435 |
| NIH project number | 5R35GM147482-05 |
| Project ID | NIH-11396385 on NIH RePORTER |
Who could benefit from this research
✓Could help
This work is primarily laboratory-based; no direct patient participation is required for this stage.
✕Less likely to help
No immediate patient treatment or participation is expected in this phase.
What this research studies
This project will develop a membrane-based assay to measure lipid peroxidation in a controlled setting, helping to clarify how oxidation damage forms in cells. By applying surface-selective fluorescence microscopy, the team will observe peroxide formation and map the chemical steps involved. The goal is to connect these chemical events to cellular outcomes like ferroptosis, which may play a role in neurodegenerative disease. The results could point to new approaches for preventing or slowing damage linked to aging and Alzheimer’s disease.
Why it matters
Potential benefit: A better understanding of lipid-related damage could guide future strategies to protect brain cells in aging and Alzheimer’s disease.
How similar studies have gone: Previous work has shown lipid peroxidation is linked to cell death, but this project aims to clarify the specific chemical pathways in membranes.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Chung, Jean — Colorado State University
- Study coordinator: Chung, Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.