Membrane and protein cues shaping cell cortex during cell division in cancers
Official title: Investigating membrane and protein-dependent regulation of cortical patterning during cytokinesis
Funded at Dartmouth College · NIH-11427044 · Data updated 2026-11-12
Researchers are studying how cells change shape and divide properly, and how failures in this process can contribute to cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | August 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $449,740 |
| NIH project number | 1R35GM166148-01 |
| Project ID | NIH-11427044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cancers or conditions where cell division and cortical dynamics are relevant may benefit from discoveries translating into therapies or diagnostics.
✕Less likely to help
This basic science project may not directly provide treatments or tests to individual patients during its initial phase.
What this research studies
This project investigates how the cell membrane and the supporting actin skeleton coordinate during cytokinesis, the final step of cell division. By examining cortical excitability and the signaling circuits that drive patterns of actin assembly, the study aims to uncover the basic rules that ensure accurate cell division in adult tissues. The findings could reveal new targets to prevent genomic instability that drives cancer progression. The work combines molecular and biophysical approaches to map how cortical remodeling is controlled in dividing cells from human tissues. If successful, this could inform strategies to maintain tissue health and reduce cancer risk related to cell division errors.
Why it matters
Potential benefit: A better understanding of how cells divide could lead to new approaches to prevent cancer caused by division errors.
How similar studies have gone: Prior work showed that cortical waves and signaling circuits can regulate cytokinesis, supporting the potential for advancing this framework.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Landino, Jennifer Elaine — Dartmouth College
- Study coordinator: Landino, Jennifer Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.