Measuring tiny signals from immune cells to improve healing
Ultrasensitive quantification of cytokine release from T cells
This study is looking at how immune cells called T cells release important proteins that help control our immune responses, and it aims to find better treatments for issues like slow wound healing and cytokine release syndrome, so patients can have improved care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11090383 on NIH RePORTER |
What this research studies
This research focuses on understanding how immune cells, specifically T cells, release cytokines, which are important signaling proteins that help regulate immune responses. By developing advanced techniques to measure these cytokines at a very detailed level, the research aims to uncover how cytokine release affects conditions like delayed wound healing and cytokine release syndrome. The approach involves using innovative imaging methods to observe cytokine release in real-time and at the single-cell level, providing insights that could lead to new treatments. Patients may benefit from improved therapies targeting cytokine dysregulation, which is currently a significant gap in clinical care.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing issues related to abnormal tissue repair or immune dysregulation.
Not a fit: Patients with stable conditions that do not involve cytokine dysregulation or immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage immune responses and improve healing in patients with various conditions.
How similar studies have performed: While there has been some research on cytokine measurement, this approach is novel and aims to provide unprecedented insights into cytokine dynamics.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Hu, Ying Samuel — University of Illinois at Chicago
- Study coordinator: Hu, Ying Samuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.