Measuring Sirtuin Activity in Cancer Cells
A Bioluminescent Assay for Direct Measurement of Sirtuin Activity in Cancer Cells
['FUNDING_R21'] · VERSITI WISCONSIN, INC. · NIH-10486045
This study is working on a new way to see how certain proteins called sirtuins are working in cancer cells, which could help scientists better understand cancer and develop new treatments.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VERSITI WISCONSIN, INC. (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10486045 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new bioluminescent assay to measure the activity of sirtuins, which are proteins that play a crucial role in regulating various cellular functions, including cancer development. The assay aims to provide real-time insights into sirtuin activity within cancer cells, overcoming limitations of existing methods that are often inaccurate or lack sensitivity. By using a novel luciferase-based approach, the researchers hope to create a reliable tool for studying sirtuins in both laboratory and animal models, which could aid in drug development and understanding cancer biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer who may benefit from targeted therapies that modulate sirtuin activity.
Not a fit: Patients with non-malignant conditions or those not diagnosed with cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for assessing cancer treatment effectiveness and developing new therapies targeting sirtuin activity.
How similar studies have performed: While the approach of using bioluminescent assays is established, the specific application to real-time measurement of sirtuin activity in cancer cells is relatively novel and has not been extensively tested.
Where this research is happening
MILWAUKEE, UNITED STATES
- VERSITI WISCONSIN, INC. — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEININGER, MICHAEL W. — VERSITI WISCONSIN, INC.
- Study coordinator: DEININGER, MICHAEL W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer