Measuring protein networks in human samples for cancer treatment
Clinical translation of a NexGen platform for quantifying protein networks in human biospecimens
This study is working on a new way to test proteins in small samples from cancer patients to help doctors get more accurate results and improve treatments, making it easier to find the best care for each individual.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10979669 on NIH RePORTER |
What this research studies
This research focuses on advancing a new technology called multiple reaction monitoring mass spectrometry (MRM-MS) to analyze protein networks in small clinical samples. By optimizing this technology, the team aims to improve the accuracy and sensitivity of protein assays used in clinical trials, particularly for cancer treatments. The research involves developing standardized procedures to ensure consistent results across different labs and samples, which is crucial for effective patient care. Patients' biospecimens will be analyzed to better understand the biological processes involved in cancer, potentially leading to more targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment for cancer who are providing biospecimens for analysis.
Not a fit: Patients with non-cancerous conditions or those not participating in clinical trials may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise cancer treatments by enabling better understanding and quantification of protein networks involved in cancer progression.
How similar studies have performed: Previous research has shown success in using similar mass spectrometry techniques for protein analysis in clinical settings, indicating a promising approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Paulovich, Amanda G — Fred Hutchinson Cancer Center
- Study coordinator: Paulovich, Amanda G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.