Measuring NAD levels in human samples for clinical use
Official title: Validation of NAD+ measurements for human clinical studies: multi-method inter-laboratory standardization
Funded at University of Pennsylvania · NIH-10978752 · Data updated 2026-11-12
This study is all about finding better ways to measure a substance called NAD and its related compounds in your blood and urine, which could help us understand how they affect your health and diseases, especially if you're considering NAD supplements.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,001,704 |
| NIH project number | 1U01AG089107-01 |
| Project ID | NIH-10978752 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the therapeutic effects of NAD supplements or those with conditions potentially linked to NAD metabolism.
✕Less likely to help
Patients who are not interested in NAD supplementation or do not have conditions related to NAD metabolism may not benefit from this research.
What this research studies
This research focuses on improving the measurement of NAD and its metabolites in human blood and urine to better understand their role in health and disease. By developing standardized methods for analyzing these compounds, the study aims to overcome current technical challenges and inconsistencies in measurement techniques. The research will involve a multidisciplinary team and utilize advanced methods such as liquid chromatography-mass spectrometry and magnetic resonance spectroscopy to ensure accurate results. Ultimately, this work seeks to provide reliable data that can inform clinical trials and therapeutic applications involving NAD supplements.
Why it matters
Potential benefit: If successful, this research could lead to more effective use of NAD supplements in treating various health conditions.
How similar studies have gone: Previous research has shown promise in measuring NAD levels, but this study aims to standardize and validate these methods for broader clinical application.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Reddy, Ravinder — University of Pennsylvania
- Study coordinator: Reddy, Ravinder
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.