Measuring myelin loss and recovery in stroke patients
Official title: Quantitative clinical imaging of demyelination and remyelination in ischemic stroke
Funded at University of Washington · NIH-11046910 · Data updated 2026-11-12
This study is looking at how a part of the brain called myelin is affected after a stroke, using special MRI scans to see how it changes over time, and it’s for people who have had an ischemic stroke to help understand their recovery better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $541,109 |
| NIH project number | 1R01NS136227-01A1 |
| Project ID | NIH-11046910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently suffered an ischemic stroke and are undergoing rehabilitation.
✕Less likely to help
Patients who have not experienced a stroke or have chronic neurological conditions unrelated to ischemic stroke may not benefit from this research.
What this research studies
This research investigates how myelin, a crucial component of brain structure, is affected in patients who have experienced an ischemic stroke. By using advanced magnetic resonance imaging (MRI) techniques, the study aims to quantify the loss and recovery of myelin in stroke patients, linking these changes to clinical outcomes and functional recovery. The research will also explore the relationship between myelin damage and the overall extent of brain injury, providing insights into the healing process after a stroke.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for stroke patients, enhancing recovery outcomes.
How similar studies have gone: Previous animal studies have shown promising results regarding myelin damage and repair in stroke, but this research aims to translate those findings into clinical practice, making it a novel approach.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Yarnykh, Vasily L. — University of Washington
- Study coordinator: Yarnykh, Vasily L.
Related research
Other NIH-funded projects on the same topics.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
-
Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.