Measuring mitochondrial DNA changes to understand biological aging
Mitochondrial DNA Deletion Mutation Frequency as a Metric of Biologic Age
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11023109
This study is looking at how changes in your DNA might help us understand your biological age and see if anti-aging treatments really work, so we can find better ways to keep you healthy as you get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11023109 on ClinicalTrials.gov |
What this research studies
This research investigates how the frequency of mitochondrial DNA deletions can serve as a biomarker for biological age and the effectiveness of anti-aging interventions. By analyzing DNA samples from various tissues, the study aims to quantify these deletions using a highly sensitive digital PCR assay. The goal is to establish a reliable measure that correlates with cellular health and aging, potentially guiding future treatments aimed at extending healthspan and reducing age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are interested in understanding their biological aging process and may be undergoing interventions to improve their healthspan.
Not a fit: Patients with acute illnesses or those who are not experiencing age-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new way to assess biological age and the effectiveness of interventions aimed at improving health in older adults.
How similar studies have performed: Previous research has shown promise in using mitochondrial DNA as a biomarker for aging, suggesting that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANAGAT, JONATHAN — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: WANAGAT, JONATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.