Measuring immune activity in chronic lesions to improve treatment for multiple sclerosis
Official title: Quantification of the Innate Immune Activity within Chronic Lesions as a Novel Treatment Biomarker in Multiple Sclerosis
Funded at Weill Medical Coll of Cornell Univ · NIH-11044154 · Data updated 2026-11-12
This study is looking to find a new way to measure ongoing inflammation in people with multiple sclerosis by using a special imaging technique, and it will help us understand how well current treatments are working on certain types of brain lesions, so we can provide better, more personalized care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $586,792 |
| NIH project number | 5R01NS136864-02 |
| Project ID | NIH-11044154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis who exhibit chronic active lesions.
✕Less likely to help
Patients with other neurological conditions or those without chronic active lesions may not benefit from this research.
What this research studies
This research aims to develop a new biomarker for chronic inflammation in multiple sclerosis (MS) using a technique called quantitative susceptibility mapping (QSM). By focusing on chronic active lesions, particularly a subgroup known as paramagnetic rim lesions, the study will track changes in inflammation over time and assess how current therapies affect these lesions. Patients will be monitored to see how their lesions respond to treatment, which could lead to more personalized and effective care.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with multiple sclerosis by providing a reliable way to monitor inflammation and treatment response.
How similar studies have gone: Previous research has shown promise in using imaging techniques to monitor inflammation in MS, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Gauthier, Susan a — Weill Medical Coll of Cornell Univ
- Study coordinator: Gauthier, Susan a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.