Measuring immune activity in chronic lesions to improve treatment for multiple sclerosis
Quantification of the Innate Immune Activity within Chronic Lesions as a Novel Treatment Biomarker in Multiple Sclerosis
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11044154
This study is looking to find a new way to measure ongoing inflammation in people with multiple sclerosis by using a special imaging technique, and it will help us understand how well current treatments are working on certain types of brain lesions, so we can provide better, more personalized care for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11044154 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new biomarker for chronic inflammation in multiple sclerosis (MS) using a technique called quantitative susceptibility mapping (QSM). By focusing on chronic active lesions, particularly a subgroup known as paramagnetic rim lesions, the study will track changes in inflammation over time and assess how current therapies affect these lesions. Patients will be monitored to see how their lesions respond to treatment, which could lead to more personalized and effective care.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who exhibit chronic active lesions.
Not a fit: Patients with other neurological conditions or those without chronic active lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with multiple sclerosis by providing a reliable way to monitor inflammation and treatment response.
How similar studies have performed: Previous research has shown promise in using imaging techniques to monitor inflammation in MS, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAUTHIER, SUSAN A — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: GAUTHIER, SUSAN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: axon injury, axonal injury