Measuring how well vaccines work against respiratory viruses like COVID-19 and influenza.
Official title: RFA-IP-22-004:Michigan-Ford Initiative to Measure Vaccine Effectiveness (MFIVE): Seasonal Influenza, COVID-19 and Respiratory Virus Vaccines
Funded at University of Michigan at Ann Arbor · NIH-10908243 · Data updated 2026-11-12
This study is looking at how well vaccines for the flu, COVID-19, and other respiratory viruses work by collecting samples from patients with respiratory illnesses at clinics in Southeastern Michigan, especially in communities that are hit harder by these diseases, to help us understand their effectiveness in real-time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,400,000 |
| NIH project number | 5U01IP001193-03 |
| Project ID | NIH-10908243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals presenting with acute respiratory illness at outpatient clinics in Southeastern Michigan.
✕Less likely to help
Patients who are not experiencing respiratory illness or who are not located in the Southeastern Michigan area may not benefit from this research.
What this research studies
This research focuses on evaluating the effectiveness of vaccines for seasonal influenza, COVID-19, and other respiratory viruses through active surveillance in outpatient settings. Patients presenting with acute respiratory illness will be recruited from various clinics across Southeastern Michigan, including those serving communities disproportionately affected by these diseases. The study will analyze patient samples for antibodies and viral genomes to provide a comprehensive assessment of vaccine effectiveness. By building on previous research, the initiative aims to deliver real-time insights into how well these vaccines prevent illness.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies and recommendations, enhancing public health responses to respiratory viruses.
How similar studies have gone: Previous studies have successfully utilized similar methodologies to assess vaccine effectiveness, indicating a strong foundation for this research.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Martin, Emily Toth — University of Michigan at Ann Arbor
- Study coordinator: Martin, Emily Toth
Related research
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This grant supports a national effort to track how well respiratory vaccines work in everyday clinics and homes.
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Vaccine effectiveness in Michigan: how well flu, COVID-19 and other respiratory vaccines work
This project tests how well vaccines against flu, COVID-19, and other respiratory viruses prevent medically attended illness in people visiting outpatient clinics in Southeastern Michigan.
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How well flu, COVID-19, and other respiratory vaccines protect people in southeastern Michigan
This project checks how well seasonal flu, COVID-19, and other respiratory vaccines protect people who visit clinics for coughs, colds, or breathing problems in southeastern Michigan.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.