Measuring how well vaccines prevent respiratory illnesses like flu and COVID-19.

RFA-IP-22-004, US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings

NIH-funded research Duke University · NIH-10908244

This study is looking at how well vaccines for the flu, COVID-19, and other respiratory viruses work to keep people healthy when they visit their doctors, and it's for anyone interested in understanding the real-life benefits of these vaccines in everyday settings.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionDuke University NIH-funded
Lab location1 site (Durham, United States)
Project IDNIH-10908244 on NIH RePORTER

What this research studies

This research focuses on evaluating the effectiveness of vaccines for seasonal influenza, COVID-19, and other respiratory viruses in preventing acute illnesses in outpatient settings. The Duke Human Vaccine Institute will coordinate efforts with the CDC to gather and analyze data on vaccine performance. By leveraging their extensive experience in clinical investigations, the team will facilitate communication and collaboration among various stakeholders involved in the research. The project aims to provide insights into how well these vaccines work in real-world scenarios, particularly in community and household environments.

Who could benefit from this research

Good fit: Ideal candidates for participation include individuals who receive seasonal influenza or COVID-19 vaccinations and are experiencing respiratory symptoms.

Not a fit: Patients who are not vaccinated against influenza or COVID-19 may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved vaccine strategies that enhance public health by reducing the incidence of respiratory illnesses.

How similar studies have performed: Previous research has demonstrated the effectiveness of similar approaches in evaluating vaccine performance, indicating a strong potential for success in this project.

Where this research is happening

Durham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.