Measuring how well vaccines prevent respiratory illnesses like flu and COVID-19.
Official title: RFA-IP-22-004, US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings
Funded at Duke University · NIH-10908244 · Data updated 2026-11-12
This study is looking at how well vaccines for the flu, COVID-19, and other respiratory viruses work to keep people healthy when they visit their doctors, and it's for anyone interested in understanding the real-life benefits of these vaccines in everyday settings.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $750,000 |
| NIH project number | 5U01IP001194-03 |
| Project ID | NIH-10908244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals who receive seasonal influenza or COVID-19 vaccinations and are experiencing respiratory symptoms.
✕Less likely to help
Patients who are not vaccinated against influenza or COVID-19 may not benefit from this research.
What this research studies
This research focuses on evaluating the effectiveness of vaccines for seasonal influenza, COVID-19, and other respiratory viruses in preventing acute illnesses in outpatient settings. The Duke Human Vaccine Institute will coordinate efforts with the CDC to gather and analyze data on vaccine performance. By leveraging their extensive experience in clinical investigations, the team will facilitate communication and collaboration among various stakeholders involved in the research. The project aims to provide insights into how well these vaccines work in real-world scenarios, particularly in community and household environments.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies that enhance public health by reducing the incidence of respiratory illnesses.
How similar studies have gone: Previous research has demonstrated the effectiveness of similar approaches in evaluating vaccine performance, indicating a strong potential for success in this project.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Walter, Emmanuel B — Duke University
- Study coordinator: Walter, Emmanuel B
Related research
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How well flu, COVID-19, and other respiratory vaccines protect people in southeastern Michigan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.