Measuring how well vaccines prevent respiratory illnesses like flu and COVID-19.

RFA-IP-22-004, US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings

NIH-funded research Duke University · NIH-10617500

This study is looking at how well vaccines for the flu, COVID-19, and other respiratory viruses help keep people healthy and prevent sickness when they visit their doctors, and it's for anyone interested in understanding the real-life benefits of these vaccines.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionDuke University NIH-funded
Lab location1 site (Durham, United States)
Project IDNIH-10617500 on NIH RePORTER

What this research studies

This research aims to evaluate the effectiveness of vaccines for seasonal influenza, COVID-19, and other respiratory viruses in preventing acute illnesses in outpatient settings. The Duke Human Vaccine Institute will coordinate efforts with the CDC to gather and analyze data on vaccine performance. By leveraging their extensive experience in clinical investigations, they will facilitate communication and collaboration among various research centers. The project will include studies that assess how well these vaccines work in real-world community and household environments.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals who receive seasonal influenza or COVID-19 vaccinations and are at risk for respiratory infections.

Not a fit: Patients who are not receiving vaccinations for respiratory viruses or those with severe immunocompromised conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved vaccine strategies that better protect patients from respiratory illnesses.

How similar studies have performed: Previous research has shown success in evaluating vaccine effectiveness, indicating that this approach is grounded in established methodologies.

Where this research is happening

Durham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.