Measuring how well the heart uses oxygen with MRI
Official title: Validation of Myocardial Oxygen Extraction Fraction Measurement with MRI
Funded at Washington University · NIH-10906985 · Data updated 2026-11-12
This study is looking at how well the heart uses oxygen by using MRI scans, which could help catch early signs of heart problems like ischemia and heart failure, so patients can get the right care sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $641,786 |
| NIH project number | 5R01HL165238-02 |
| Project ID | NIH-10906985 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with known or suspected heart conditions such as ischemic cardiomyopathy, heart failure, or other cardiovascular diseases.
✕Less likely to help
Patients with healthy hearts or those without any cardiovascular issues may not receive any benefit from this research.
What this research studies
This research investigates the measurement of myocardial oxygen extraction fraction (mOEF) using MRI to better understand how the heart utilizes oxygen. By focusing on the balance between oxygen supply and consumption, the study aims to identify early signs of heart conditions such as ischemia and heart failure before mechanical dysfunction occurs. The approach involves advanced imaging techniques to assess blood flow and oxygen consumption in the heart, providing critical insights for diagnosis and monitoring. Patients may benefit from improved diagnostic methods that can lead to timely interventions.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of heart conditions, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for cardiac assessment, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Zheng, Jie — Washington University
- Study coordinator: Zheng, Jie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.