Measuring how well stem cell-derived heart cells mature
Transcriptomic Entropy to Quantify Maturation of PSC-Derived Cardiomyocytes
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10895545
This study is looking at how to help heart cells made from stem cells grow up and become more like real heart cells, so they can be used better in treatments for heart conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10895545 on ClinicalTrials.gov |
What this research studies
This research investigates the maturation of heart cells derived from pluripotent stem cells (PSC-CMs), which currently lack maturity for effective use in treatments. The team has developed a new quantitative metric based on entropy to evaluate the maturation status of these cells. By applying this metric, they aim to assess the effectiveness of various methods, including molecular stimulation and tissue engineering, in promoting PSC-CM maturation. The findings will provide insights into the maturation process and help identify potential improvements in current techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who may benefit from advanced heart cell therapies.
Not a fit: Patients with fully developed heart conditions or those over 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective heart cell therapies for patients with heart conditions.
How similar studies have performed: Previous research has shown promise in using quantitative metrics for cell maturation, indicating that this approach may yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KWON, CHULAN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: KWON, CHULAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.