Measuring how well antibiotics reach tuberculosis infection sites using advanced imaging techniques
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET Imaging
This study is looking at how well antibiotics reach the infection spots in tuberculosis patients using special imaging, so we can better understand how to improve treatments and help those who might struggle with their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10873886 on NIH RePORTER |
What this research studies
This research investigates how effectively antibiotics penetrate cavitary lesions in tuberculosis patients, which are critical areas for infection. By utilizing noninvasive PET imaging, the study aims to measure antibiotic concentrations directly at the infection sites rather than relying solely on plasma levels. This approach allows for a more accurate understanding of drug distribution and effectiveness, potentially leading to improved treatment strategies tailored to individual patient needs. The research also seeks to identify patients at risk for treatment failure, which could inform more personalized treatment plans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cavitary tuberculosis who are undergoing antibiotic treatment.
Not a fit: Patients with non-cavitary forms of tuberculosis or those not currently receiving antibiotic treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective tuberculosis treatments by ensuring that antibiotics reach the infection sites in adequate concentrations.
How similar studies have performed: Previous research has shown promise in using imaging techniques to assess drug distribution, suggesting that this approach could yield valuable insights for tuberculosis treatment.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Jain, Sanjay — Johns Hopkins University
- Study coordinator: Jain, Sanjay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.