Measuring how the brain and body respond when people choose to work for rewards

A naturalistic multimodal platform for capturing brain-body interactions in people during physical effort-based decision making

NIH-funded research Georgia Institute of Technology · NIH-11260165

This project uses a new system to record brain and body signals while people decide whether to expend physical effort for rewards, aimed at helping people with motivational problems like depression, Parkinson's, or schizophrenia.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionGeorgia Institute of Technology NIH-funded
Lab location1 site (Atlanta, United States)
Project IDNIH-11260165 on NIH RePORTER

What this research studies

You would take part in immersive tasks where you move and make effortful choices in a virtual environment while wearing sensors. The HORMES system synchronizes measurements across brain signals, bodily responses, movement, and clinical/affective behavior in real time. Researchers will use a naturalistic effort-based decision-making task that requires walking or other physical effort to obtain rewards. The goal is to capture how decisions, feelings, and body signals link together in everyday-like behavior.

Who could benefit from this research

Good fit: Ideal candidates are adults who experience reduced motivation or effort for rewards (for example from depression, Parkinson's disease, or schizophrenia) and who can safely perform the study's physical walking or movement tasks.

Not a fit: People with severe mobility limitations, unstable medical conditions, or severe cognitive impairment that prevent safe participation in the physical or VR tasks are unlikely to benefit from joining this project.

Why it matters

Potential benefit: If successful, this could reveal measurable brain–body signatures of motivational problems that help guide better diagnosis, monitoring, or future treatments.

How similar studies have performed: Previous work on effort-based decision-making and multimodal monitoring exists, but combining immersive, naturalistic locomotion tasks with synchronized brain–body measurement is a novel approach that is still early-stage.

Where this research is happening

Atlanta, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.