Measuring how the body processes phenylalanine in certain metabolic disorders
Quantitative Measurement of Phenylalanine Metabolism in Sapropterin-Responsive Hyperphenylalaninemia
This study is looking at new, gentle ways to see how your body processes phenylalanine, especially if you have PAH deficiency, by testing breath samples and blood levels after a special diet, to help improve future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10701016 on NIH RePORTER |
What this research studies
This research focuses on developing noninvasive techniques to measure how the body metabolizes phenylalanine, particularly in individuals with phenylalanine hydroxylase (PAH) deficiency. The study will evaluate two methods: analyzing breath samples after consuming a specific form of phenylalanine and measuring blood levels of phenylalanine and tyrosine after a fasting challenge. These methods aim to provide reliable data on phenylalanine metabolism without being affected by dietary intake. The findings will help prepare for future clinical trials involving gene therapy for PAH deficiency.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with full or partial phenylalanine hydroxylase deficiency.
Not a fit: Patients without phenylalanine hydroxylase deficiency or those who do not meet the age requirement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment options for patients with phenylalanine metabolism disorders.
How similar studies have performed: Previous research has shown promise in using noninvasive methods for metabolic measurements, suggesting potential success for this approach.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Harding, Cary O. — Oregon Health & Science University
- Study coordinator: Harding, Cary O.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.