Measuring how stress affects sickle blood cells using advanced imaging techniques
Single-cell measurement of cyclic stress on sickle blood cells by imaging-microfluidics
This study is looking at how stress affects certain red blood cells in people with sickle cell disease, especially those that might cause painful crises, to help find out who might be at greater risk for these complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10839805 on NIH RePORTER |
What this research studies
This research investigates how mechanical stress impacts red blood cells (RBCs) in patients with sickle cell disease, particularly focusing on a subpopulation of 'unfit' RBCs that may contribute to painful vaso-occlusive crises (VOC). By employing innovative imaging techniques, the study aims to understand how repeated sickling and mechanical stress alter the properties of these cells, potentially leading to increased VOC risk. The researchers will develop a next-generation imaging platform to analyze these changes in detail, which could help identify patients at higher risk for complications. This approach combines advanced microscopy with microfluidic assays to provide insights into the biophysical behavior of sickle cells under stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sickle cell disease, particularly those experiencing frequent vaso-occlusive crises.
Not a fit: Patients with other forms of anemia or blood disorders unrelated to sickle cell disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of sickle cell disease, potentially reducing the frequency and severity of vaso-occlusive crises.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques to understand sickle cell disease, but this specific approach is relatively novel.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: So, Peter T. — Massachusetts Institute of Technology
- Study coordinator: So, Peter T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.