Measuring how proteins interact with DNA in living cells
Official title: Rapid and robust assay for measurement of in vivo activity of chromatin-interacting proteins
Funded at Epicypher, INC. · NIH-10890874 · Data updated 2026-11-12
This study is working on a new, easy way for scientists to measure important proteins that help control how our genes work in living cells, which could lead to better treatments for various health conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Epicypher, INC. NIH-funded |
| Lab location | 1 site (Research Triangle Park, UNITED STATES) |
| Project start | July 19, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,008,869 |
| NIH project number | 5R44AI179547-02 |
| Project ID | NIH-10890874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with autoimmune diseases or other conditions where gene expression regulation is disrupted.
✕Less likely to help
Patients with conditions unrelated to chromatin-associating proteins or gene expression regulation may not receive any benefit from this research.
What this research studies
This research focuses on developing a new assay to measure the activity of chromatin-associating proteins (CAPs), which play a crucial role in regulating gene expression. The goal is to create a high-throughput, low-cost method that allows researchers to quantify CAPs in their active forms directly in living cells. By improving access to this technology, the research aims to enhance our understanding of cellular processes in both health and disease, potentially leading to new therapeutic strategies. The approach involves genomic mapping and innovative assay techniques to provide detailed insights into CAP engagement and localization.
Why it matters
Potential benefit: If successful, this research could provide a transformative tool for researchers, enabling better understanding and treatment of various diseases linked to gene regulation.
How similar studies have gone: Other research has shown success with similar high-throughput assay approaches, indicating a promising potential for this novel method.
Where this research is happening
-
Epicypher, INC.
Research Triangle Park, United States Active
Researchers
- Principal investigator: Sun, Zu-Wen — Epicypher, INC.
- Study coordinator: Sun, Zu-Wen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.