Measuring how proteins are made and broken down in the body using heavy water.
Official title: Protein turnover estimation from fragment ions and precursor enrichment in heavy water labeled LC-MS experiments
Funded at University of Texas Med Br Galveston · NIH-10804187 · Data updated 2026-11-12
This study is looking at new ways to measure how fast proteins break down in the body using heavy water, and it's for anyone interested in understanding how protein changes might relate to different diseases, with tests done on animals like mice and dogs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $387,375 |
| NIH project number | 1R01GM149762-01A1 |
| Project ID | NIH-10804187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with metabolic disorders or conditions that affect protein turnover.
✕Less likely to help
Patients with stable metabolic conditions or those not affected by protein turnover issues may not benefit from this research.
What this research studies
This research focuses on improving methods to estimate how quickly proteins are turned over in the body by using heavy water as a labeling agent. By analyzing protein samples from various animal models, including mice and dogs, the researchers aim to enhance the accuracy and efficiency of protein turnover measurements. The study employs advanced mass spectrometry techniques to analyze fragment ions, which can provide more reliable data than traditional methods. Ultimately, this research seeks to better understand protein dynamics in relation to diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of protein metabolism, which may inform treatments for various diseases.
How similar studies have gone: Previous research has shown promise in using heavy water labeling for protein studies, indicating that this approach has potential for success.
Where this research is happening
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University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Sadygov, Rovshan G — University of Texas Med Br Galveston
- Study coordinator: Sadygov, Rovshan G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.