Measuring how new drugs interact with brain targets using PET imaging
Validation of Occupancy Images from PET Data. A Novel Endpoint for Drug Discovery
This study is looking at a new way to see how well potential new drugs attach to certain spots in the brain, which could help create better treatments for brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11031928 on NIH RePORTER |
What this research studies
This research focuses on improving the measurement of how new drug candidates bind to specific sites in the brain using advanced PET imaging techniques. By developing a new method that extends the traditional Lassen plot, the study aims to provide more accurate data on drug occupancy at these binding sites, which is crucial for determining the effectiveness of drugs in treating central nervous system conditions. The approach involves analyzing PET data to understand regional variations in drug binding, which can help optimize drug development processes. Patients may benefit from this research as it could lead to more effective treatments for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions who may be participating in early-phase clinical trials for new drug therapies.
Not a fit: Patients with conditions unrelated to the central nervous system or those not involved in drug trials may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug candidates for treating brain-related conditions.
How similar studies have performed: Previous research has shown success in using PET imaging for drug development, but this specific approach is novel and aims to address limitations of existing methods.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Morris, Evan D — Yale University
- Study coordinator: Morris, Evan D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.