Measuring how gene activity changes over time in single cells
Official title: Measuring and modeling gene expression trajectories: new computational-experimental approaches
Funded at Boston University (Charles River Campus) · NIH-11412668 · Data updated 2026-11-12
A funded project at Boston University will study how RNA production and breakdown change in individual human cells using new computational and experimental methods.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $449,625 |
| NIH project number | 5R35GM160123-02 |
| Project ID | NIH-11412668 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older, especially those with conditions affecting tissues and cells where RNA dynamics are relevant.
✕Less likely to help
People without conditions involving dynamic gene expression or without access to advanced single-cell analyses may see no direct benefit.
What this research studies
This project aims to map how genes turn on and off over time in single human cells to understand normal biology and disease-related changes. It combines experimental data with advanced machine learning to model RNA velocity and kinetic rates. By linking dynamic gene behavior to cell states, the work could reveal regulatory patterns that drive tissue function and disease progression.
Why it matters
Potential benefit: If successful, it could improve our understanding of how cells adapt in health and disease, potentially guiding new treatments that target gene regulation.
How similar studies have gone: Prior work in single-cell RNA velocity has shown promise in revealing dynamic gene regulation, with ongoing efforts to improve accuracy and interpretation.
Where this research is happening
-
Boston University (Charles River Campus)
Boston, United States Active
Researchers
- Principal investigator: Cleary, Brian Lowman — Boston University (Charles River Campus)
- Study coordinator: Cleary, Brian Lowman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.